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KMID : 1130620200160040674
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Journal of Clinical Neurology
2020 Volume.16 No. 4 p.674 ~ p.680
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Tacrolimus for Treating Orbital and Cranial Form of Idiopathic Inflammatory Pseudotumors
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Kim Hyun-Jae
Lee Seon-Kyung
Koo Yu-Jin
Kwon Eun-Jin
Kim Hyo-Jung
Choi Jeong-Yoon
Kim Ji-Soo
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Abstract
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Background and Purpose: Orbital and cranial form of idiopathic inflammatory pseudotumors (IIPs) are rare disorders with heterogeneous clinical presentations. Corticosteroids have been the first-line treatment for IIPs, but they are not always effective.
Methods: We reviewed the medical records of three patients with orbital or cranial form of IIP who were treated with tacrolimus as an adjuvant treatment.
Results: The three patients showed favorable outcomes with the addition of tacrolimus, which is a calcineurin inhibitor that inhibits T-cell activation and T-cell-dependent B-cell activation.
Conclusions: Tacrolimus may be a safe and effective immunosuppressant for refractory or relapsing form of orbital or cranial IIPs.
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KEYWORD
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tacrolimus, inflammatory pseudotumor, Tolosa-Hunt syndrome, orbital pseudotumor
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